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| Host Species | Rabbit |
| Species Reactivity | C. elegans, Human, Mouse, Bovine, Insect, Plant |
| Conjugate | NONE |
| Immunogen | Synthetic peptide based on human LRRK2 protein sequence. |
| Epitope | The epitope is in the AA 2500-2527 of LRRK2. |
| Format | Liquid or Lyophilized |
| Cellular Localization | Mitochondrial outer membrane |
| Purification | Affinity purified |
| Product Overview | This product is a Rabbit antibody against the AA 2500-2527 of the LRRK2. It can be used for LRRK2 detection in Western Blot, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunoprecipitation, Knockout Validated. |
| Target Name | LRRK2 |
| Gene ID | 120892 |
| UniProt ID | H9F555 |
| Introduction | Leucine-rich repeat kinase 2 (LRRK2), and PARK8 (derived from early recognition of Parkinson's disease), is a kinase gene encoded by human LRRK2. LRRK2 is a member of the leucine-rich repeat kinase family. Variations in this gene are associated with increased risk of Parkinson's disease and Crohn's disease. The expression of mutant LRRK2 induces apoptosis in neuroblastoma cells and mouse cortical neurons. The expression of LRRK2 mutants associated with autosomal dominant Parkinson's disease leads to shortening and simplification of dendritic trees in vivo and in cultured neurons. RRK2 is also a substrate for partner-mediated autophagy. |
| Application | FACS, FACS-IC, IF, IHC, IHC-Fr, IHC-P, IP, WB |
| Application Notes | Western Blot 1-2 µg/mL Flow Cytometry 2.5 µg/mL Immunocytochemistry/Immunofluorescence 2-5 µg/mL Immunohistochemistry 1:200 Immunohistochemistry-Frozen Immunohistochemistry-Paraffin 1:200 Immunoprecipitation 1:10-1:500 Flow (Intracellular) 2.5 µg/mL |
| Shipping | Shipped on dry ice. |
| Storage | Store at 4 °C: short-term (1-2 weeks) Store at -20 °C: long-term and future use |
| Buffer | PBS |
For Research Use Only. Not For Clinical Use.Related Products
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