Probiotics are commonly defined as viable, non-pathogenic microorganisms (including bacteria and/or yeast). The health benefits of probiotics are strictly strain-specific, despite belonging to the same species distinct strains may have different effects. Therefore, accurate characterization of novel potentially probiotic strains is required, and appears to be particularly important. As excellent model organisms, C. elegans is becoming an increasingly valuable in vivo model for studying host-probiotic interactions and providing mechanistic insights into the beneficial effects of probiotics. At CD BioSciences, we utilize a combination of expertise in C. elegans research and advanced technologies to provide high-quality, cost-effective probiotic screening services.

C. elegans for Probiotics Screening

C. elegans is an excellent model organism for studying the potential benefits of probiotic strains, providing valuable insights into host-microbe interactions, and helping to identify potential probiotics with health-promoting properties. C. elegans is an excellent model organism for probiotic screening because of the following advantages:

• Feeding on Bacteria and Fungi: The free-living nematodes Caenorhabditis elegans reside in the soil and decaying organic matter, where they feed on bacteria and fungi. For C. elegans, microbes can be food (for example, as part of a beneficial gut microbiome), pathogens, parasites, and even competitors.
• A Key Similarity to Human Intestine: As a differentiated multi-cellular organism, C. elegans is similar to mammals in many aspects of physiology. The C. elegans intestine is composed of 20 non-renewable epithelial cells. Despite the simple composition, the nematode has polarized epithelial cells with microvilli.
• Excellent System for Biological Studies: C. elegans has numerous advantages, including short reproductive cycle, the transparent gut, ease of handling, and the ability to create a defined gut microbiota make it an ideal candidate organism for testing the effects of ingested bacteria on host physiology.

Fig.1 Schematic representation of signaling pathways influenced by probiotics in C. elegans studies. (Roselli M, et al., 2019)

Our Services

With its simple anatomy, short lifespan, and well-characterized genetics, C. elegans provides valuable insights into host-microbe interactions, helping researchers identify potential probiotics. At CD BioSciences, we are committed to providing cutting-edge services in C. elegans research, including probiotic screening services.

Workflow of Our Services

Why Choose CD BioSciences?

CD BioSciences is a professional C. elegans model service provider. We have developed a simple, rapid, and economic high-throughput screening system for potential probiotics using C. elegans as a in vivo model. If you have any demands for screening potential probiotics, please don't hesitate to contact us for more information.

Reference

1. Roselli M, Schifano E, Guantario B, et al. Caenorhabditis elegans and probiotics interactions from a prolongevity perspective[J]. International Journal of Molecular Sciences, 2019, 20(20): 5020.

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