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The stresses, such as oxidative stress, heat stress, osmotic stress, and anoxia stress, have received significant attention in terms of their effects on gene expression, physiology and signaling pathways. Many organisms have stress response pathways, and among them, studies of the C. elegans stress response, including heat shock, oxidative stress, hypoxic stress, and osmotic stress, have provided detailed insights into the genetic and molecular mechanisms of human diseases (e.g., cancers, neurodegenerative disorders, etc.) and potential targets for drug discovery. Here, CD BioSciences exploits several types of stress response experiments combined with C. elegans to help our customers detect the genes and pathways underlying human disease and access potential targets for drug discovery.
Researchers have identified many common stress-induced effects on physiology, gene expression and signaling pathways. Since its introduction, C. elegans has been an important platform for biological research and for the implementation of a large number of technologies, and this tiny, transparent worm has been widely used in many areas of genetics, developmental and evolutionary biology, and complex disease research. As an important model for human disease research, C. elegans shares many biological characteristics with humans. In addition, many C. elegans signaling pathways are conserved in lifespan extension, apoptosis, and complex behaviors.
Fig.1 Schematic representation of stress response in a Caenorhabditis elegans cell. (Rodriguez M, et al., 2013)
Stress response studies in C. elegans have been conducted mainly from the perspectives of longevity genetics, neurobiology, and developmental biology. In addition, since C. elegans stress response has highly homologous genes and pathways with humans and plays an important role in various complex diseases. Therefore, the analysis of the C. elegans stress response can provide opportunities for the discovery of new receptors and drug targets for the treatment of various diseases.
| Stress | C. elegans Gene | Human Homolog | Disease |
|---|---|---|---|
| Heat-shock | daf-18 | PTEN | Cancer |
| daf-16 | FOXO3A | Cancer | |
| hsf-1 | HSF1 | Cancer | |
| Oxidative | pink-1 | PINK1 | Parkinson's |
| lrk-1 | LRRK2 | Parkinson's | |
| sod-1, -2, -3 | SOD1, 2, 3 | Amyotrophic lateral sclerosis (ALS) | |
| Hypoxia | hif-1 | HIF | Ischemia, cancer |
| vhl-1 | VHL | Cancer | |
| egl-9 | EGLN | Cancer | |
| Osmotic | gpdh-1 | GPD1 | Transient infantile hypertriglyceridemia |
| elt-2, -3 | GATA4–6 | Pancreatic agenesis and cardiac defects | |
| osm-12 | BBS7 | Bardet–Biedl syndrome |
The C. elegans model system has been applied in many studies and has proven instrumental in studying stress responses for defining the genes, genetic pathways, and molecular mechanisms that give rise to diverse physiological processes. At CD BioSciences, our experienced scientists and technicians will work closely with you to provide high-quality C. elegans stress analysis services that will help you gain insights into disease biological processes such as aging, development, and disease. Our services include but are not limited to:
Customized
We tailor our services to your specific research needs to ensure that the C. elegans stress analysis symbolizes your research objectives.
Expertise
CD BioSciences' team consists of experienced scientists who are well versed in C. elegans research, ensuring that you obtain high quality and reliable results.
Fast Turnaround
We utilize advanced technology and employ streamlined processes to ensure that your experiments are executed efficiently, and results are delivered in a timely manner.
CD BioSciences is dedicated to providing the best service to accelerate the achievement of our customers' research goals. We focus on the stress model system in C. elegans to assist customers in understanding the genetics of longevity, neurobiology, and developmental biology. If you are interested in our services, please don't hesitate to contact us for more details.
Reference
For research use only.
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