Lipids play an important role in biology, from biofilm construction to signaling and energy storage. Metabolomics is the latest in "histology" technology, and lipidomic has evolved from metabolomics to characterize the lipid content of a given organism or system. C. elegans lipidomic analysis encompasses a variety of different possibilities, ranging from lipid droplet visualization, to total fatty acid analysis, to the analysis of complex lipids using a lipidomic approach. At CD BioSciences, we are committed to providing you with comprehensive C. elegans lipidomic analysis services. Equipped with advanced technologies and deep expertise, our talented team of experts will work closely with you so that we can provide you with groundbreaking insights in areas ranging from aging and metabolism to neurobiology and drug development.

Introduction to Lipidomic Analysis

In the post-genomic era, researchers are placing greater emphasis on the use of functional genomics tools, including transcriptomics, proteomics, and metabolomics. The purpose of genomics is to functionally analyze genes and genomes in order to study different subparts within a cell or organism. Metabolomics is an emerging field in biology, and as a branch of metabolomics, lipidomic aims to characterize lipophilic metabolites in biological systems. The analysis of lipids is important because of their role in cell membranes, energy storage and signaling. Lipidomic is categorized into targeted and untargeted lipidomic.

• Targeted lipidomic is the quantification of a few to hundreds of lipids.
• Non-targeted lipidomic refers to the large-scale analysis of lipids in organisms, aiming to explore all lipids in an organism.

Fig.1 C. elegans deep lipidome profiling by using integrative mass spectrometry acquisitions reveals significantly altered lipid networks. (Anh N H, et al., 2022)

With the rapid development of high-throughput technologies and high-resolution mass spectrometry (HRMS), researchers are able to explore lipid diversity and their multiple biological functions. As a result, lipidomic, a rapidly growing field, has provided insightful solutions for the exploration of metabolism in a wide range of organisms. Current techniques used for lipidomic analysis include imaging lipid deposition in C. elegans using fluorescent dyes or other techniques, analyzing lipid fractions by chromatography, and analyzing fatty acid composition by gas chromatography and gas chromatography-mass spectrometry. Among these, mass spectrometry serves as a powerful tool for deciphering different lipid species and enabling relative and/or absolute quantification of lipids.

Our Services

Lipidomic, a subcategory of metabolomics, helps researchers explore lipid homeostasis and network information in biological systems on a large scale, and has important applications in clinical, biomedical, pharmaceutical analysis and environmental sciences. As an expert in C. elegans research, CD BioSciences offers comprehensive C. elegans lipidomic analysis services with advanced technology platforms and extensive expertise, including identification and quantification of lipid classes, subclasses, and individual lipid species, as well as providing you with a comprehensive overview of the lipid landscape.

Why Choose CD BioSciences?

Whether you are exploring developmental mysteries, unraveling disease mechanisms or drug screening, CD BioSciences' C. elegans lipidomic analysis services can advance your research. With our experienced scientists and advanced and mature technology platform, we are confident that we can provide you with high-quality customized solutions based on your specific needs. We guarantee that all deliverables will undergo rigorous quality testing and be delivered on time. If you are interested in our services or have any questions, please feel free to contact us.

References

1. Anh N H, Yoon Y C, Min Y J, et al. Caenorhabditis elegans deep lipidome profiling by using integrative mass spectrometry acquisitions reveals significantly altered lipid networks[J]. Journal of Pharmaceutical Analysis, 2022, 12(5): 743-754.
2. Witting M, Schmitt-Kopplin P. The Caenorhabditis elegans lipidome: A primer for lipid analysis in Caenorhabditis elegans[J]. Archives of biochemistry and biophysics, 2016, 589: 27-37.